A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum.
نویسندگان
چکیده
A new cytotoxic polyhydroxysterol, 23,24-dimethylcholest-16(17)-E-en-3beta,5alpha,6beta,2 0(S)-tetraol (2), together with nine known compounds was isolated from the soft coral Sarcophyton trocheliophorum. Their structures were determined by spectroscopic methods. Compound 2 showed potent growth inhibitory activity against human HL60 leukemia, M14 skin melanoma, and MCF7 breast carcinoma cells with EC50 values of 2.8, 4.3, and 4.9 microg/ml, respectively, and exhibited minimal toxicity to normal human peripheral blood lymphocytes.
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 48 7 شماره
صفحات -
تاریخ انتشار 2000